Document Detail


Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats.
MedLine Citation:
PMID:  22326640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A negative influence of central chemosensitivity on peripheral chemoreflex response has been demonstrated recently in a decerebrate-vagotomized rat preparation in situ with separate carotid body and brainstem perfusions. Here, we report similar negative influences of hypercapnia on the hypoxic respiratory response in anesthetized, spontaneously breathing rats before and after vagotomy and anesthetized, artificially ventilated rats after vagotomy. Baseline breathing patterns and responsiveness to hypercapnia and hypoxia varied widely between the three respiratory modes. Despite this, the responses in inspiratory amplitude and expiratory duration (and hence respiratory frequency and neural ventilation) to hypoxia varied inversely with the background CO2 level in all three groups. Results demonstrate a hypoadditive hypercapnic-hypoxic interaction in vivo that resembles the hypoadditive central-peripheral chemoreceptor interaction in situ for these respiratory variables in the rat, regardless of differences in vagal feedback, body temperature and ventilation method. These observations stand in contrast to previous reports of hyperadditive peripheral-central chemoreceptor interaction.
Authors:
Chung Tin; Gang Song; Chi-Sang Poon
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-02
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  181     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-07     Completed Date:  2012-08-06     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / physiopathology*
Carbon Dioxide / blood
Carotid Body / physiopathology*
Chemoreceptor Cells / physiology*
Hypercapnia / physiopathology*
Male
Oxygen / blood
Phrenic Nerve / physiopathology
Rats
Rats, Sprague-Dawley
Respiration*
Vagotomy
Vagus Nerve / physiology*,  surgery
Grant Support
ID/Acronym/Agency:
HL067966/HL/NHLBI NIH HHS; HL093225/HL/NHLBI NIH HHS; R01 HL067966/HL/NHLBI NIH HHS; R01 HL093225/HL/NHLBI NIH HHS; RC1 RR028241/RR/NCRR NIH HHS; RR028241/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen
Comments/Corrections

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