Document Detail

Hypercalciuria is related to osmolar excretion in children with nocturnal enuresis.
MedLine Citation:
PMID:  19914655     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We evaluated the incidence of hypercalciuria, defined as urinary calcium-to-creatinine ratio greater than 0.21 mg/mg, in children with nocturnal enuresis, and the association with concurrent values of diuresis and osmolar excretion. MATERIALS AND METHODS: A total of 550 children admitted to a tertiary university center were included in the study. A 24-hour urine collection was performed in 8 sampling periods for measurement of calcium excretion, osmolality and diuresis. RESULTS: Of the children with nocturnal enuresis 12% had 24-hour hypercalciuria. Up to 29% of the timed urine samples exhibited hypercalciuria. There was a significant correlation between calcium excretion and nocturnal diuresis volume (polyuria), low urinary osmolality, and increased sodium and osmolar excretion of nighttime urine samples (all p <0.001). CONCLUSIONS: Patients referred to a tertiary enuresis center have a high incidence of hypercalciuria. However, the significant correlation between hypercalciuria and osmolar excretion and diuresis suggests that it is a comorbid factor rather than a primary pathogenic factor. As such, we cannot confirm the data from Italian studies relating nocturnal enuresis to primary hypercalciuria, and suggest instead an association with nutritional intake.
A Raes; L Dossche; N Hertegonne; L Nuytemans; P Hoebeke; E Van Laecke; R Donckerwolcke; J Vande Walle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  183     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  AIM; IM    
Department of Pediatric Nephrology, University Hospital Ghent, Ghent, Belgium.
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MeSH Terms
Hypercalciuria / epidemiology,  etiology*
Nocturnal Enuresis / complications*,  metabolism*
Osmolar Concentration
Comment In:
J Urol. 2010 Jan;183(1):301   [PMID:  19914664 ]

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