Document Detail

Hypercalcemia with excess serum 1,25 dihydroxyvitamin D in lymphomatoid granulomatosis/angiocentric lymphoma.
MedLine Citation:
PMID:  2000889     Owner:  NLM     Status:  MEDLINE    
Hypercalcemia has been described in a variety of granulomatous and lymphoproliferative disorders in association with elevated serum levels of 1,25-dihydroxyvitamin D. In such cases, hypercalcemia appears to be the consequence of excessive production of 1,25(OH)2D by the lymphocyte/macrophage line. The authors report a patient with lymphomatoid granulomatosis/angiocentric lymphoma who developed hypercalcemia with extreme elevation in serum 1,25(OH)2D. Therapy with steroids reduced the serum calcium and 1,25(OH)2D levels to normal. Hypercalcemia has not previously been reported in lymphomatoid granulomatosis/angiocentric lymphoma. The distinctive features of this malignancy, and the derangement in the metabolism of 1,25(OH)2D in lymphoproliferative disorders in general, are discussed.
S J Scheinman; M W Kelberman; A H Tatum; K W Zamkoff
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  301     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-09     Completed Date:  1991-04-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  AIM; IM    
Department of Medicine, SUNY Health Science Center, Syracuse 13210.
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MeSH Terms
Calcitriol / blood*
Hypercalcemia / blood*,  etiology
Lymphoma / blood*,  pathology
Lymphomatoid Granulomatosis / blood*,  complications,  pathology
Middle Aged
Grant Support
Reg. No./Substance:

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