Document Detail

Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review.
MedLine Citation:
PMID:  15694824     Owner:  NLM     Status:  MEDLINE    
Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.
Susanna L Matsen; Charles J Yeo; Ralph H Hruban; Michael A Choti
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract     Volume:  9     ISSN:  1091-255X     ISO Abbreviation:  J. Gastrointest. Surg.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706084     Medline TA:  J Gastrointest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-9     Citation Subset:  IM    
Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.
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MeSH Terms
Hypercalcemia / blood*
Liver Neoplasms / blood,  radiography,  secondary,  surgery
Middle Aged
Pancreatic Neoplasms / blood*,  pathology,  physiopathology,  surgery
Parathyroid Hormone-Related Protein / analysis*,  blood*
Pregnancy Complications / blood*,  physiopathology
Tomography, X-Ray Computed
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein

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