| Hypercalcemia in two patients with sarcoidosis and Mycobacterium avium intracellulare not mediated by elevated vitamin D metabolites. | |
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MedLine Citation:
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PMID: 21760475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: To describe 2 unusual cases of hypercalcemia due to granulomatous diseases with normal vitamin D metabolites and no other ready explanation for the hypercalcemia. METHODS: We present the clinical, laboratory and pathologic findings of 2 patients with hypercalcemia and review previous reports of hypercalcemia in granulomatous diseases without elevated vitamin D metabolites. RESULTS: Hypercalcemia was described in various granulomatous diseases including sarcoidosis, tuberculosis, berylliosis, leprosy and, rarely, in fungal infections. Elevated serum level of vitamin D or its metabolites was linked to the pathogenesis of hypercalcemia in these disorders. The authors present the clinical, laboratory and pathologic findings in 2 patients who presented with hypercalcemia and normal vitamin D metabolites with no other ready explanation for the hypercalcemia. The first patient was diagnosed with Mycobacterium avium, whereas the second patient was found to have sarcoidosis. CONCLUSION: Although hypercalcemia in granulomatous diseases has been attributed to be mediated by elevated vitamin D metabolites, there have been several case reports that documented normal values of active vitamin D metabolites. This report illustrates the regulatory feedback mechanisms of vitamin D synthesis and introduces the term "inappropriately normal" vitamin D metabolites levels in light of low levels of parathyroid hormone. |
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Authors:
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Muhammad Z Shrayyef; Zsolt DePapp; William T Cave; Steven D Wittlin |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 342 ISSN: 1538-2990 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: 2011-11-08 Revised Date: 2011-12-30 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 336-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Moncton City Hospital, Moncton, Canada. Dr.Muhammad.Shrayyef@horizonNB.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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complications,
metabolism Adult Feedback, Physiological Granulomatous Disease, Chronic / blood, complications Humans Hypercalcemia / blood*, etiology* Male Middle Aged Mycobacterium avium-intracellulare Infection / blood*, complications* Parathyroid Hormone / blood Sarcoidosis / blood*, complications* Vitamin D / blood*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 1406-16-2/Vitamin D |
| Comments/Corrections | |
Comment In:
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Am J Med Sci. 2011 Dec;342(6):539
[PMID:
22108173
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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