| Hypercalcemia Associated with Mineral Oil-Induced Sclerosing Paraffinomas. | |
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MedLine Citation:
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PMID: 23337133 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Granuloma-forming diseases such as sarcoidosis are associated with extra-renal synthesis of 1, 25-dihydroxyvitamin D [1, 25(OH)2 D]. Here, we describe a case of extensive skin lesions associated with mineral oil injections in which we provide evidence for cutaneous granuloma synthesis of 1,25(OH)2 D in the pathogenesis of the patient's hypercalcemia.Methods: Analysis of expression of the 1-a OHase (CYP27b1) was carried out by immunohistochemical analysis of involved skin.Results: In involved skin, expression of CYP27b1 was found in the dermis, where it is not normally expressed. Successful management of hypercalcemia was achieved with glucocorticoids.Conclusions: Hypercalcemia associated with mineral oil induced skin lesions is likely driven by unregulated expression of CYP27b1 by inflammatory monocytes and macrophages infiltrating the dermis. |
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Authors:
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Andreas G Moraitis; Michael Collins; Martin Hewison; Candido Anaya; Michael F Hollick |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-21 |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: - ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: - |
Other Details:
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Languages: ENG Pagination: 1-19 Citation Subset: - |
Affiliation:
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Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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