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Hypercalcemia Associated with Mineral Oil-Induced Sclerosing Paraffinomas.
MedLine Citation:
PMID:  23337133     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Granuloma-forming diseases such as sarcoidosis are associated with extra-renal synthesis of 1, 25-dihydroxyvitamin D [1, 25(OH)2 D]. Here, we describe a case of extensive skin lesions associated with mineral oil injections in which we provide evidence for cutaneous granuloma synthesis of 1,25(OH)2 D in the pathogenesis of the patient's hypercalcemia.Methods: Analysis of expression of the 1-a OHase (CYP27b1) was carried out by immunohistochemical analysis of involved skin.Results: In involved skin, expression of CYP27b1 was found in the dermis, where it is not normally expressed. Successful management of hypercalcemia was achieved with glucocorticoids.Conclusions: Hypercalcemia associated with mineral oil induced skin lesions is likely driven by unregulated expression of CYP27b1 by inflammatory monocytes and macrophages infiltrating the dermis.
Authors:
Andreas G Moraitis; Michael Collins; Martin Hewison; Candido Anaya; Michael F Hollick
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  -     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-19     Citation Subset:  -    
Affiliation:
Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland.
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