| Hyperbranched Polyglycerols As Trimodal Imaging Agents: Design, Biocompatibility and Tumor Uptake. | |
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MedLine Citation:
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PMID: 22304718 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Combining various imaging modalities often leads to complementary information and synergistic advantages. A trimodal long-circulating imaging agent tagged with radioactive, magnetic resonance and fluorescence markers is able to combine the high sensitivity of SPECT with the high resolution of MRI over hours and days. The fluorescence marker helps to confirm the in vivo imaging information at the microscopic level, in the context of the tumour microenvironment. To make a trimodal long-circulating probe, high molecular weight hyperbranched polyglycerols (HPG) were modified with a suitable ligand for 111In radiolabelling and Gd coordination, and additionally tagged with a fluorescent dye. The resulting radiopharmaceutical and contrast agent was non-toxic and hemocompatible. Measured radioactively, its total tumor uptake increased from 2.6% at 24 h to 7.3% at 72 h, which is twice the increase expected due to tumor growth in this time period. Both in vivo MRI and subsequent histological analyses of the same tumors confirmed maximum HPG accumulation at 3 days post injection. Furthermore, Gd-derivatized HPG has an excellent contrast enhancement on T1-weighted MRI at 10x lower molar concentrations than commercially available Galbumin. HPG derivatized with gadolinium, radioactivity and fluorescence are thus long-circulating macromolecules with great potential for imaging of healthy and leaky blood vessels using overlapping multi-modal approaches and for the passive targeting of tumors. |
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Authors:
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Katayoun Saatchi; Peter Soema; Nikolaus Gelder; Ripen Misri; Kelly McPhee; Jennifer H E Baker; Stefan Reinsberg; Donald E Brooks; Urs O Hafeli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
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Title: Bioconjugate chemistry Volume: - ISSN: 1520-4812 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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