| Hyperbolic correlation between insulin sensitivity and insulin secretion fades away in lean subjects with superb glucose regulation. | |
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MedLine Citation:
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PMID: 22094999 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The relationship between insulin sensitivity (Si) and insulin secretion (β) was analyzed in 533 health examinees. The subjects underwent a 75 g oral glucose tolerance test, with plasma glucose (PG) and immunoreactive insulin (IRI) determined at fasting, 30 min and 120 min, and were classified according to the current criteria as normal glucose tolerance (NGT, n=328), non-diabetic hyperglycemia (NDH, n=113) including impaired fasting glucose and impaired glucose tolerance, and diabetes mellitus (DM, n=72). NGT was subdivided by fasting PG (FPG) tertile, ≤4.9, 5.0-5.4 and 5.5-6.0 mM, into NGT(FPG1), NGT(FPG2) and NGT(FPG3), or by body mass index (BMI) tertile, ≤21.8, 21.9-24.4 and ≥24.5 kg/m(2), into NGT(BMI1), NGT(BMI2) and NGT(BMI3). As an index of Si and β, Matsuda index=10,000/sqrt[FPG·FIRI·2hPG·2hIRI] and δIRI(0-30)/δPG(0-30), were employed respectively: FIRI, 2hPG and 2hIRI denote fasting IRI, 2h-post glucose PG and IRI, respectively. Correlation between Si and β was evaluated by Spearman's rank correlation and the parameters for [β]=a·[Si](b) were obtained by standardized major axis (SMA) regression. Si-β correlation was strongest in NDH (Spearman's rho=-0.546, SMA regression r(2)=0.277), intermediate in DM (rho=-0.432, r(2)=0.193) and weakest in NGT (rho=-0.201, r(2)=0.039). Spearman's rho for the Si-β correlation was significantly lower in NGT than in NDH (p=0.003). Si-β correlation was significant in NGT(FPG3), NGT(FPG2) and NGT(BMI3), but not in NGT(FPG1), NGT(BMI2) and NGT(BMI1). The slope, b, was -1.184(~)-1.530 without significant differences between any groups. In conclusion, the hyperbolic Si-β correlation was weaker in NGT than in NDH and absent in NGT subjects belonging to the lowest FPG or BMI tertile. |
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Authors:
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Toru Aizawa; Masayuki Yamada; Masafumi Katakura; Yoshiko Funase; Koh Yamashita; Keishi Yamauchi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-18 |
Journal Detail:
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Title: Endocrine journal Volume: - ISSN: 1348-4540 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Diabetes Center, Aizawa Hospital, Matsumoto, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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