Document Detail

Hyperbilirubinemia in preterm infants and neurodevelopmental outcome at 2 years of age: results of a national collaborative survey.
MedLine Citation:
PMID:  2471139     Owner:  NLM     Status:  MEDLINE    
As part of a prospective national survey of preterm and small for gestational age infants in the Netherlands, the relationship between maximal serum total bilirubin concentration in the neonatal period and neurodevelopmental outcome at the corrected age of 2 years was studied. Initially, 1,338 infants with a gestational age of less than 32 completed weeks and/or a birth weight of less than 1,500 g were enrolled in the study; 146 were subsequently excluded because of congenital malformations and 361 died during the study period. At the corrected age of 2 years, 831 children were available for follow-up. Children with minor and major handicaps had significantly greater maximal serum total bilirubin concentrations than children with a normal neurodevelopmental outcome (P = .02). A consistent increase in prevalence of handicaps was found for each 50-mumol/L (2.9 mg/dL) increase of maximal serum total bilirubin concentration. The handicaps consisted mainly of cerebral palsy. Logistic regression analysis involving seven suspected confounding factors (gestational age, birth weight, seizures, intracranial hemorrhage, respiratory distress syndrome, ventriculomegaly, and bronchopulmonary dysplasia) revealed that the odds ratio was 1.3. This indicates that, on a multiplicative scale, the risk of a handicap increased by 30% for each 50-mumol/L (2.9 mg/dL) increase of maximal serum total bilirubin concentration (P = .02). Further analysis treated bilirubin as a categorized exposure. A striking systematic increase was found, suggesting a causal relationship between maximal serum total bilirubin concentration and neurodevelopmental outcome.
M van de Bor; T M van Zeben-van der Aa; S P Verloove-Vanhorick; R Brand; J H Ruys
Related Documents :
13679929 - Increased incidence of parenteral nutrition-associated cholestasis with aminosyn pf com...
21273989 - Why do families of sick newborns accept hospital care? a community-based cohort study i...
15203259 - Elevated serum cardiac troponin i in rhabdomyolysis.
3098349 - Efficacy of phototherapy in non-haemolytic hyperbilirubinaemia.
16761009 - Does intensive phototherapy produce hemolysis in newborns of 35 or more weeks gestation?
6854459 - Endogenous substance in newborn infants causing false positive digoxin measurements.
21517959 - Cerebral resistance index is less predictive in hypothermic encephalopathic newborns.
11477969 - Every death counts: measurement of maternal mortality via a census.
8330579 - Twenty-four-hour ambulatory eeg monitoring in infantile spasms.
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  83     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-06     Completed Date:  1989-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  915-20     Citation Subset:  AIM; IM    
Department of Pediatrics, University Hospital, Leiden, the Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bilirubin / blood
Cerebral Palsy / blood,  epidemiology,  etiology
Child, Preschool
Developmental Disabilities / blood,  epidemiology*,  etiology
Follow-Up Studies
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood,  epidemiology*,  mortality
Infant, Small for Gestational Age
Jaundice, Neonatal / blood,  complications,  epidemiology*,  mortality
Multicenter Studies as Topic
Prospective Studies
Regression Analysis
Reg. No./Substance:
Comment In:
Pediatrics. 1990 Mar;85(3):379-80   [PMID:  2304793 ]
Pediatrics. 1993 Jan;91(1):164; author reply 165-6   [PMID:  8416494 ]
Pediatrics. 1993 Jan;91(1):164-5; author reply 165-6   [PMID:  7677968 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Proto-oncogene expression and dissection of the myeloid growth to differentiation developmental casc...
Next Document:  Status of the blood-brain barrier in newborn infants of various gestational ages in the normal state...