Document Detail

Hyperbilirubinemia in the breast-fed newborn: a controlled trial of four interventions.
MedLine Citation:
PMID:  8424029     Owner:  NLM     Status:  MEDLINE    
A controlled clinical trial was conducted to compare the effect of four different interventions on hyperbilirubinemia in 125 full-term breast-fed infants. Of 1685 term infants who met the inclusion criteria, 126 (7.4%) had a serum bilirubin concentration > or = 291 mumol/L (17 mg/dL). When the bilirubin reached this level, babies were assigned at random to one of four interventions: (1) continue breast-feeding and observe; (2) discontinue breast-feeding, substitute formula; (3) discontinue breast-feeding, substitute formula and administer phototherapy; (4) continue breast-feeding, administer phototherapy. The serum bilirubin concentration reached 342 mumol/L (20 mg/dL) in 24% of infants in group 1, 19% in group 2, 3% in group 3, and 14% in group 4. When phototherapy was used, the decline in serum bilirubin was significantly larger and more rapid (compared with no phototherapy). In the majority of breast-fed infants whose serum bilirubin levels reach 291 mumol/L (17 mg/dL) the bilirubin will decline spontaneously and will not reach 342 mumol/L (20 mg/dL). If the infant is significantly jaundiced and a decision is made to intervene, parents can be given a number of options and can make an informed decision regarding which, if any, intervention they prefer.
J C Martinez; M J Maisels; L Otheguy; H Garcia; M Savorani; B Mogni; J C Martinez
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatrics     Volume:  91     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  470-3     Citation Subset:  AIM; IM    
Hospital Materno Infantil R. Sarda, Buenos Aires, Argentina.
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MeSH Terms
Analysis of Variance
Bilirubin / blood
Birth Weight
Bottle Feeding / standards*
Breast Feeding*
Combined Modality Therapy
Delivery, Obstetric / methods
Gestational Age
Infant, Newborn
Jaundice, Neonatal / blood,  etiology,  prevention & control*
Labor Presentation
Phototherapy / methods,  standards*
Treatment Outcome
Reg. No./Substance:

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