Document Detail

Hyperbilirubinemia following exposure to pancuronium bromide in newborns.
MedLine Citation:
PMID:  2397674     Owner:  NLM     Status:  MEDLINE    
We investigated the risk of hyperbilirubinemia in relation to the administration of pancuronium bromide among newborn infants requiring mechanical ventilation. One hundred and twenty-nine infants treated with pancuronium were compared to 129 infants who were never exposed, matched on ventilatory status, hospital, birthweight, initial total serum bilirubin, and date of hospital discharge. Overall, the adjusted summary relative risk (RR) for hyperbilirubinemia among pancuronium-exposed infants compared to nonexposed infants was 1.2 (95% confidence interval 1.1-1.4). The risk was greatest among exposed infants during the 4 days following the last dose of pancuronium (RR = 1.4; 1.0-1.8). These data suggest that the use of pancuronium in sick newborns may be associated with an increased risk of clinically important hyperbilirubinemia.
J Freeman; S M Lesko; A A Mitchell; M F Epstein; S Shapiro
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  14     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1990  
Date Detail:
Created Date:  1990-10-15     Completed Date:  1990-10-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Mass.
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MeSH Terms
Bilirubin / blood
Hyperbilirubinemia / chemically induced*
Infant, Newborn
Pancuronium / adverse effects*
Respiration, Artificial
Risk Factors
Grant Support
223-74-3196//PHS HHS; MCJ 250484//PHS HHS; R01 HD 17958/HD/NICHD NIH HHS
Reg. No./Substance:
0/Pancuronium; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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