| Hyperbaric oxygen therapy for late sequelae in women receiving radiation after breast-conserving surgery. | |
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MedLine Citation:
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PMID: 11240244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Persisting symptomatology after breast-conserving surgery and radiation is frequently reported. In most cases, symptoms in the breast resolve without further treatment. In some instances, however, pain, erythema, and edema can persist for years and can impact the patient's quality of life. Hyperbaric oxygen therapy was shown to be effective as treatment for late radiation sequelae. The objective of this study was to assess the efficacy of hyperbaric oxygen therapy in symptomatic patients after breast cancer treatment. PATIENTS AND METHODS: Forty-four patients with persisting symptomatology after breast-conservation therapy were prospectively observed. Thirty-two women received hyperbaric oxygen therapy in a multiplace chamber for a median of 25 sessions (range, 7-60). One hundred percent oxygen was delivered at 240 kPa for 90-min sessions, 5 times per week. Twelve control patients received no further treatment. Changes throughout the irradiated breast tissue were scored prior to and after hyperbaric oxygen therapy using modified LENT-SOMA criteria. RESULTS: Hyperbaric oxygen therapy patients showed a significant reduction of pain, edema, and erythema scores as compared to untreated controls (p < 0.001). Fibrosis and telangiectasia, however, were not significantly affected by hyperbaric oxygen therapy. Seven of 32 women were free of symptoms after hyperbaric oxygen therapy, whereas all 12 patients in the control group had persisting complaints. CONCLUSIONS: Hyperbaric oxygen therapy should be considered as a treatment option for patients with persisting symptomatology following breast-conserving therapy. |
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Authors:
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U M Carl; J J Feldmeier; G Schmitt; K A Hartmann |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 49 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-03-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1029-31 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University Duesseldorf, Duesseldorf, Germany. umcarl@uni-duesseldorf.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Breast Diseases
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therapy Breast Neoplasms / radiotherapy*, surgery Case-Control Studies Edema / therapy Female Fibrosis / therapy Humans Hyperbaric Oxygenation* Pain / therapy Prospective Studies Radiation Injuries / therapy* Radiodermatitis / therapy Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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