Document Detail

Hyperbaric oxygen therapy of cerebral ischemia.
MedLine Citation:
PMID:  16230845     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperbaric oxygen (HBO) therapy of cerebral ischemia has been evaluated in a number of human and animal studies; however, there is presently no consensus on its efficacy. METHODS: We present a review of animal and human studies on HBO therapy of cerebral ischemia as well as present potential mechanisms of action of HBO. RESULTS: Animal studies of HBO have shown promise by reducing infarct size and improving neurologic outcome. HBO has also been shown to inhibit inflammation and apoptosis after cerebral ischemia. Early reports in humans also suggested benefit in stroke patients treated with HBO. Recent randomized, controlled human studies, however, have not shown benefit, although all were limited by small sample size. Important differences between animal and human studies suggest HBO might be more effective in stroke within the first few hours and at a pressure of 2-3 ATA. CONCLUSIONS: The clinical usefulness of HBO in the treatment of cerebral ischemia is not yet certain. Attention to emerging pathophysiologic data should be taken into consideration in design of any future clinical trials of HBO in acute ischemic stroke.
Ann K Helms; Harry T Whelan; Michel T Torbey
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-10-17
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  20     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2005  
Date Detail:
Created Date:  2005-11-21     Completed Date:  2006-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  417-26     Citation Subset:  IM    
Copyright Information:
2005 S. Karger AG, Basel
Medical College of Wisconsin, Milwaukee, Wisc. 53226, USA.
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MeSH Terms
Brain Ischemia / therapy*
Clinical Trials as Topic
Hyperbaric Oxygenation* / adverse effects,  trends
Stroke / therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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