Document Detail


Hyperbaric oxygen and pulmonary surface tension.
MedLine Citation:
PMID:  1174314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous work has shown that short-term exposure of cats to oxygen at high pressure (OHP), to the extent of overt convulsive seizures, has little or no effect on the lung appearance or lung weight but does alter the alveolar surfactants. More prolonged exposure results in hemorrhagic edema of the cat lung similar to that observed in rats after only short-term exposure. Previous work showed that sympathetic stimulation via the stellate ganglion and mechanical CNS injury results in altered surfactants attributed to increased intra-alveolar cholesterol. In the present study, cats exposed to OHP until the animals convulsed intermittently for 3 min (approximately 1 hour, 6 ATA) similarly showed altered surfactants with a high minimum surface tension and a 150% increase in intra-alveolar cholesterol. These changes also occurred in the absence of any gross lung injury. The results from the present study suggest that an important causal mechanism involved in the development of gross lung injury associated with prolonged OHP exposure is an initial increase in minimum surface tension due to increased intra-alveolar cholesterol.
Authors:
D R Bergren; D L Beckman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  46     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-12-04     Completed Date:  1975-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  994-5     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Cholesterol / analysis
Hemorrhage / chemically induced
Lung / pathology
Oxygen / toxicity*
Pulmonary Alveoli / analysis,  physiopathology*
Pulmonary Edema / chemically induced
Pulmonary Surfactants
Seizures / chemically induced
Surface Tension
Time Factors
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants; 57-88-5/Cholesterol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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