Document Detail


Hyperbaric oxygen in the treatment of clostridial gas gangrene.
MedLine Citation:
PMID:  3207345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-two cases with clostridial gas gangrene were treated during the years 1971-87 in the Department of Surgery, Turku University Central Hospital. The presumptive diagnosis was made on the basis of the clinical appearance of the patient and presence of gram-positive bacilli on a smear. Each patient underwent surgical debridement, antibiotic therapy and hyperbaric oxygen treatment. Seventeen cases had diffuse spreading myonecrosis, 11 of whom survived. Fifteen patients developed clostridial cellulitis with toxicity, 12 survived. Thus the over-all mortality was 28.1%. All those patients who died had been transferred from other hospitals of the country and were already moribund on arrival. Twenty-two infections developed postoperatively, in 6 cases trauma was the antedecent cause and 4 were spontaneous infections. None of the patients with a posttraumatic infection died. The most common underlying disorders included arteriosclerosis, diabetes mellitus, malignancy and Buerger's disease. The addition of hyperbaric oxygenation to the treatment of gas gangrene--although strictly adjunctive to surgery, antibiotics and supportive therapy--has dramatically changed the surgical approach to treatment. Early diagnosis remains essential. Patient survival can be achieved if the disease is recognized early and appropriate therapy applied promptly.
Authors:
M Hirn; J Niinikoski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annales chirurgiae et gynaecologiae     Volume:  77     ISSN:  0355-9521     ISO Abbreviation:  Ann Chir Gynaecol     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7609767     Medline TA:  Ann Chir Gynaecol     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Female
Finland
Gas Gangrene / mortality,  therapy*
Humans
Hyperbaric Oxygenation*
Male
Middle Aged
Postoperative Complications / therapy
Risk Factors
Surgical Wound Infection / therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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