Document Detail

Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning.
MedLine Citation:
PMID:  20369650     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Delayed neuropsychiatric syndrome (DNS) is characterized by mental impairment, motor dysfunction, dementia, or psychosis that develops between a few days and weeks after acute carbon monoxide (CO) poisoning. One possible mechanism responsible for CO-mediated encephalopathy involves oxidative stress, such as lipid peroxidation, caused by the cellular uptake of CO and which leads to an inflammatory cascade. There is no current effective treatment for DNS. We applied 8-40 sessions of hyperbaric oxygen therapy (HBO2) to patients with DNS and evaluated its effectiveness. METHODS: After admission, all patients were administered piracetam or bromocriptine, or both, and received HBO2. Neuropsychiatric tests included EEG, mini-mental status examination (MMSE), brain MRI, event-related potential (ERP), and brain perfusion scan (brain SPECT). Results of these tests were compared before and after HBO2, and the clinical features were monitored during this period. RESULTS: The symptoms of DNS for all patients improved significantly after HBOT. Although white matter changes remained evident in the brain MRI scans, other examinations such as EEG, MMSE, ERP, and 99mTc-ECD brain SPECT were nearly normal after HBOT. CONCLUSION: Our results suggest that HBO2 decreases the severity of impairment in patients with DNS. Although a large randomized trial is required to address the efficacy of this therapy, therapeutic application of HBO2 may be recommended in patients with DNS after CO poisoning.
D C Chang; J T Lee; C P Lo; Y M Fan; K L Huang; B H Kang; H L Hsieh; S Y Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc     Volume:  37     ISSN:  1066-2936     ISO Abbreviation:  Undersea Hyperb Med     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312954     Medline TA:  Undersea Hyperb Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-33     Citation Subset:  IM; S    
Department of Neurology, Chu Shang Show Chwan Hospital, Nantou, Taiwan, Republic of China.
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MeSH Terms
Carbon Monoxide Poisoning / complications,  diagnosis,  therapy*
Dementia / etiology,  therapy
Hyperbaric Oxygenation*
Magnetic Resonance Imaging
Mental Disorders / diagnosis,  etiology,  therapy*
Middle Aged
Movement Disorders / etiology,  therapy*
Psychotic Disorders / etiology,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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