| Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. | |
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MedLine Citation:
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PMID: 18756476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy. METHODS: Female individuals with epilepsy and regular menstrual cycles were eligible for this prospective study. Participants were randomized to 12 months of valproate (n = 225) or lamotrigine (n = 222) therapy. Serum androgen levels were measured every 3 months. Urinary pregnanediol glucuronide levels were measured weekly for two 3-month periods. The primary end point was development of PCOS components (ie, hyperandrogenism or ovulatory dysfunction). A post hoc analysis was conducted in women more than 2 years after menarche (177 lamotrigine, (HA) 186 valproate) to exclude OD the confounding effect of puberty. RESULTS: More women in the valproate group than the lamotrigine group developed (OD) in the prospective (54% valproate, 38% lamotrigine; p = 0.010) and the post hoc (HA) analyses (36% valproate, 23% lamotrigine; p = 0.007). More women in the valproate group than the lamotrigine group developed PCOS (9 vs 2%; p = 0.007). Development of HA was more frequent with OD valproate than lamotrigine among those initiating treatment at age younger than 26 years (44% valproate, 23% lamotrigine; p = 0.002) but was similar if treatment was started at age 26 years or older (24% valproate, 22% lamotrigine). INTERPRETATION: Development of HA occurred more frequently with valproate than lamotrigine, especially if medication was started at age younger than 26 years. |
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Authors:
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Martha J Morrell; Frances J Hayes; Patrick M Sluss; Judith M Adams; Mohit Bhatt; Cigdem Ozkara; Clay R Warnock; Jouko Isojärvi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 64 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-09-03 Completed Date: 2008-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 200-11 Citation Subset: IM |
Affiliation:
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Stanford University, Stanford and Neuropace, Mountain View, CA 94043, USA. mmorrell@neuropace.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anovulation / chemically induced, drug therapy Epilepsy / drug therapy Female Humans Hyperandrogenism / chemically induced, drug therapy* Internationality Ovulation / drug effects*, physiology Polycystic Ovary Syndrome / chemically induced, drug therapy* Prospective Studies Triazines / adverse effects, pharmacology, therapeutic use* Valproic Acid / adverse effects, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Triazines; 84057-84-1/lamotrigine; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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