Document Detail


Hyperandrogenic states in pregnancy.
MedLine Citation:
PMID:  21114372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperandrogenic states in pregnancy are almost always the result of a condition that arises during pregnancy. The onset of virilization symptoms is often very fast. The mother is protected against hyperandrogenism by a high level of SHBG, by placental aromatase and a high level of progesterone. The fetus is protected from the mother's hyperandrogenism partly by the placental aromatase, that transforms the androgens into estrogens, and partly by SHGB. Nevertheless there is a significant risk of virilization of the female fetus if the mother's hyperandrogenic state is serious. The most frequent cause of hyperandrogenic states during pregnancy are pregnancy luteoma and hyperreactio luteinalis. Hormonal production is evident in a third of all luteomas, which corresponds to virilization in 25-35 % of mothers with luteoma. The female fetus is afflicted with virilization with two thirds of virilized mothers. Hyperreactio luteinalis is created in connection with a high level of hCG, e.g. during multi-fetus pregnancies. This condition most frequently arises in the third trimester, virilization of the mother occurs in a third of cases. Virilization of the fetus has not yet been described. The most serious cause of hyperandrogenism is represented by ovarian tumors, which are fortunately rare.
Authors:
N Kaňová; M Bičíková
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-11-29
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  60     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-10     Completed Date:  2011-09-09     Revised Date:  2011-10-21    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  243-52     Citation Subset:  IM    
Affiliation:
Institute of Endocrinology, Prague, Czech Republic. nkanova@endo.cz
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MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Neoplasms / metabolism
Adrenal Glands / metabolism,  ultrasonography
Adrenocortical Adenoma / metabolism,  ultrasonography
Adrenocortical Carcinoma / metabolism,  ultrasonography
Adult
Androgens / biosynthesis*,  physiology
Aromatase / deficiency
Female
Fetus / metabolism
Humans
Hyperandrogenism / complications,  metabolism*,  ultrasonography
Luteoma / metabolism,  ultrasonography
Ovarian Neoplasms / metabolism,  ultrasonography
Ovary / metabolism,  ultrasonography
Placenta / enzymology
Pregnancy
Pregnancy Complications / metabolism*,  ultrasonography
Ultrasonography, Prenatal
Virilism / etiology,  metabolism*,  ultrasonography
Chemical
Reg. No./Substance:
0/Androgens; EC 1.14.14.1/Aromatase

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