Document Detail

Hyperaminoacidemia due to the accumulation of gluconeogenic amino acid precursors in hypoglycemic small-for-gestational age infants.
MedLine Citation:
PMID:  1165519     Owner:  NLM     Status:  MEDLINE    
The postnatal (3 to 12 hours) plasma amino acid patterns of normal full-term, nonhypoglycemic, and hypoglycemic small-for-gestational age infants were compared. Seventeen amino acid were separated by automatic column chromatography. It was found that hypoglycemia in SGA newborn infants was associated with a marked increase in total serum amino acid concentrations. This hyperaminoacidemia, which was mainly due to the increase in concentrations of alanine, glycine, proline, and valine, apparently reflected a decreased heapatic gluconeogenic capacity. A significant inverse correlation was observed between concentration of blood glucose and the accumulation of gluconeogenic amino acids. The proportionate accumulation of alanine, glycine, proline, and valine suggests a closely interrelated production and release of these amino acids from the peripheral pools. It is concluded that the changes in concentrations of plasma amino acids occurring in hypoglycemic SGA infants can be helpful in understanding the relative contribution of individual amino acids to gluconeogenesis in the human infant.
J Mestyán; G Soltész; K Schultz; M Horváth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  87     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-11     Completed Date:  1975-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-14     Citation Subset:  AIM; IM    
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MeSH Terms
Alanine / blood
Amino Acids / blood*
Birth Weight*
Gestational Age*
Glycine / blood
Hypoglycemia / metabolism*
Infant, Newborn
Infant, Newborn, Diseases / metabolism*
Maternal-Fetal Exchange
Nutrition Disorders / metabolism
Proline / blood
Valine / blood
Reg. No./Substance:
0/Amino Acids; 147-85-3/Proline; 56-40-6/Glycine; 56-41-7/Alanine; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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