| Hyperaldosteronism and hypertension: ethnic differences. | |
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MedLine Citation:
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PMID: 15699471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study is to evaluate the relationship between aldosterone and blood pressure in a total of 220 normotensive and 293 essential hypertensive subjects in 2 genetically distinct populations-blacks and white French Canadians. The 24-hour blood pressure monitoring was performed under standardized conditions after discontinuing antihypertensive medications. Plasma renin activity and plasma aldosterone were measured in the supine position and after standing for 10 minutes. Plasma atrial natriuretic factor was also measured. Supine and standing plasma renin activities were lower (P< or =0.01), plasma aldosterone was higher (P<0.0001), and the aldosterone/renin ratios were higher (P<0.0001) in the hypertensive subjects. Atrial natriuretic factor was also higher in the hypertensive subjects (P<0.0001). Among blacks, blood pressures did not correlate with plasma renin activity. However, both average daytime and nighttime systolic and diastolic blood pressures were correlated with supine and standing plasma aldosterone and with the aldosterone/renin ratio (P<0.005 or less). In French Canadians, blood pressures tended to be positively correlated with standing plasma renin activity and aldosterone, but not with the aldosterone/renin ratio. Correlations of blood pressure with aldosterone were more consistent and more striking in blacks than in French Canadians. In both ethnic groups, there were inconsistent correlations of blood pressure with atrial natriuretic factor. These observations are consistent with the hypothesis that aldosterone-induced volume expansion is an important contributor to hypertension, especially in blacks. |
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Authors:
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Clarence E Grim; Allen W Cowley; Pavel Hamet; Daniel Gaudet; Mary L Kaldunski; Jane Morley Kotchen; Shanthi Krishnaswami; Zdenka Pausova; Richard Roman; Johanne Tremblay; Theodore A Kotchen |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2005-02-07 |
Journal Detail:
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Title: Hypertension Volume: 45 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-25 Completed Date: 2005-10-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 766-72 Citation Subset: IM |
Affiliation:
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Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group* Aldosterone / blood Atrial Natriuretic Factor / blood Blood Pressure Blood Pressure Monitoring, Ambulatory Case-Control Studies European Continental Ancestry Group* Female Humans Hyperaldosteronism / complications*, ethnology* Hypertension / blood, ethnology*, etiology*, physiopathology Male Middle Aged Renin / blood |
| Grant Support | |
ID/Acronym/Agency:
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5-M01-RR-00058/RR/NCRR NIH HHS; HL-70111/HL/NHLBI NIH HHS; P50 HL-54998/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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