| Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times. | |
| | |
MedLine Citation:
|
PMID: 20659484 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Tissue occlusion and the hyperaemic response upon reperfusion can be used as a tool to assess microvascular function in various vascular diseases. Currently, laser Doppler flowmetry (LDF) is applied most often to measure hyperaemic responses. In this study, we have applied tissue viability imaging (TiVi) and LDF to measure the change in red blood cell concentration and perfusion in the skin after occlusions of the forearm with increasing duration. We have found that there is a strong correlation between the changes in perfusion and red blood cell (RBC) concentration during post-occlusive hyperaemia (perfusion: r=0.80; RBC concentration: r=0.94). This correlation increases with longer occlusion durations (1, 5 and 10min). Furthermore, for both perfusion and RBC concentration, the maximum responses (perfusion: r(2)=0.59; RBC concentration: r(2)=0.78) and the recovery times (perfusion: r(2)=0.62; RBC concentration: r(2)=0.91) increase linearly with the duration of the occlusion. Maximum responses and recovery times were more reproducible for RBC concentration (as measured with TiVi) than for perfusion (as measured with LDF). These results show that perfusion and RBC concentration are related during post-occlusive hyperaemia and that TiVi can be used as a tool in the assessment of hyperaemic responses that has advantages in terms of reproducibility, sensitivity and ease of use. |
| | |
Authors:
|
Simon Farnebo; Johan Thorfinn; Joakim Henricson; Erik Tesselaar |
Related Documents
:
|
14529024 - Determination of erythrocyte deformability and its correlation to cellular atp release ... 3700964 - The role of the red blood cell in the transport of carbon disulfide. 11264184 - Reduced oxidative-stress response in red blood cells from p45nfe2-deficient mice. 18180274 - Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2h-naphthol[1,2-... 14632624 - Effects of ankle exercise combined with deep breathing on blood flow velocity in the fe... 3332844 - Aortic stump closure: a new technique. |
Publication Detail:
|
Type: Journal Article Date: 2010-07-24 |
Journal Detail:
|
Title: Microvascular research Volume: 80 ISSN: 1095-9319 ISO Abbreviation: Microvasc. Res. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: United States |
Other Details:
|
Languages: eng Pagination: 412-6 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Plastic Surgery, Hand Surgery, and Burns, University Hospital, Linköping, Sweden. simon.farnebo@lio.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experimental estimation of blood flow velocity through simulation of intravital microscopic imaging ...
Next Document: Albuminuria and VEGF as early markers of cardiovascular disturbances in young type 1 diabetic patien...