Document Detail

Hyperactivity induced by prenatal administration of methylazoxymethanol: association with altered performance on conditioning tasks in rats.
MedLine Citation:
PMID:  6718446     Owner:  NLM     Status:  MEDLINE    
Methylazoxymethanol (MAM), an alkylating agent which kills dividing cells, produces microcephaly when administered to rats at 15 days gestation. Rats treated prenatally with MAM were tested on a variety of behavioral tests. The MAM-treated animals performed better than controls in the acquisition of a food-reinforced operant response, but poorer than controls on a passive avoidance procedure. When required to reverse the passive avoidance procedure by actively avoiding the portion of a chamber that was associated with shock, MAM-treated rats performed better than controls. The MAM-treated rats were microcephalic and were also hyperactive compared to controls. It was postulated that the behavioral changes observed in the conditioning tasks may be attributable to hyperactivity. A possible neurochemical basis for this hyperactivity is discussed.
H E Cannon-Spoor; W J Freed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  20     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-06-05     Completed Date:  1984-06-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
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MeSH Terms
Alkylating Agents / pharmacology*
Avoidance Learning / drug effects
Azo Compounds / pharmacology*
Body Weight
Conditioning, Operant / drug effects*
Methylazoxymethanol Acetate / analogs & derivatives,  pharmacology*
Motor Activity / drug effects*
Prenatal Exposure Delayed Effects
Psychomotor Performance / drug effects*
Rats, Inbred Strains
Reg. No./Substance:
0/Alkylating Agents; 0/Azo Compounds; 590-96-5/methylazoxymethanol; 592-62-1/Methylazoxymethanol Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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