| Hyperactivity induced by prenatal administration of methylazoxymethanol: association with altered performance on conditioning tasks in rats. | |
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MedLine Citation:
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PMID: 6718446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methylazoxymethanol (MAM), an alkylating agent which kills dividing cells, produces microcephaly when administered to rats at 15 days gestation. Rats treated prenatally with MAM were tested on a variety of behavioral tests. The MAM-treated animals performed better than controls in the acquisition of a food-reinforced operant response, but poorer than controls on a passive avoidance procedure. When required to reverse the passive avoidance procedure by actively avoiding the portion of a chamber that was associated with shock, MAM-treated rats performed better than controls. The MAM-treated rats were microcephalic and were also hyperactive compared to controls. It was postulated that the behavioral changes observed in the conditioning tasks may be attributable to hyperactivity. A possible neurochemical basis for this hyperactivity is discussed. |
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Authors:
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H E Cannon-Spoor; W J Freed |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 20 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-06-05 Completed Date: 1984-06-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 189-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylating Agents
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pharmacology* Animals Avoidance Learning / drug effects Azo Compounds / pharmacology* Body Weight Conditioning, Operant / drug effects* Female Methylazoxymethanol Acetate / analogs & derivatives, pharmacology* Motor Activity / drug effects* Pregnancy Prenatal Exposure Delayed Effects Psychomotor Performance / drug effects* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Azo Compounds; 590-96-5/methylazoxymethanol; 592-62-1/Methylazoxymethanol Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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