| Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice. | |
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MedLine Citation:
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PMID: 20006657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase family member, which induces apoptosis in various cells through JNK and p38 MAP kinase cascades. In addition to apoptosis signaling, a number of recent in vitro studies have suggested that ASK1 may play roles in neural function. However, the behavioral significance of ASK1 has remained unclear. Here, we subjected ASK1 (-/-) mice to a battery of behavioral tests and found that they displayed temporary hyperactivity in an open-field test. Activities in the familiar field were normal, indicating that the hyperactivity observed was specific to the novel environment. ASK1 (-/-) mice also exhibited impairment of novelty preference 24h after training and superior performance on the rotarod test. Brain tissue contents of dopamine and 4-dihydroxyphenylacetic acid (DOPAC) were elevated in ASK1 (-/-) mice. Our findings thus demonstrate novel behavioral functions of ASK1, including regulation of locomotor activity, novelty preference, and motor coordination with dopaminergic transmission. |
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Authors:
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Karen Kumakura; Hiroshi Nomura; Takeshi Toyoda; Koichi Hashikawa; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo; Makoto Tsunoda; Takashi Funatsu; Daigo Ikegami; Minoru Narita; Tsutomu Suzuki; Norio Matsuki |
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Publication Detail:
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Type: Journal Article Date: 2009-12-16 |
Journal Detail:
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Title: Neuroscience research Volume: 66 ISSN: 1872-8111 ISO Abbreviation: Neurosci. Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-06-07 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 313-20 Citation Subset: IM |
Affiliation:
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Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism* Animals Brain / metabolism* Dopamine / metabolism* Environment Exploratory Behavior / physiology* Fear / physiology Hyperkinesis / metabolism* MAP Kinase Kinase Kinase 5 / deficiency, genetics, metabolism* Male Memory / physiology Memory Disorders / metabolism Mice Mice, Inbred C57BL Mice, Knockout Motor Activity / physiology Neuropsychological Tests Time Factors |
| Chemical | |
Reg. No./Substance:
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102-32-9/3,4-Dihydroxyphenylacetic Acid; EC 2.7.11.25/MAP Kinase Kinase Kinase 5; EC 2.7.11.25/Map3k5 protein, mouse |
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