Document Detail

Hyperactive behavior of rats after lesions of the globus pallidus.
MedLine Citation:
PMID:  987835     Owner:  NLM     Status:  MEDLINE    
Following bilateral lesions of the globus pallidus, rats living in a residential maze were hyperactive during the 12 hr dark cycle but not during the 12 hr light cycle. Lesioned rats were less exploratory during the light cycle than control rats but not during the dark cycle. Exploratory behavior of rats was photographed for 15 min during the light cycle. The duration of 6 behavior acts was significantly shorter than controls (scratching, grooming, sitting, sniffing, standing and rearing). The number of initiations of grooming, scratching, sniffing and smelling decreased while looking and walking increased in frequency. The linkage of behavior acts into sequences was diminished compared with controls. Similar, but not identical, changes were found when the structure of exploratory behavior of naive rats was compared with the exploratory behavior of experienced rats. It is concluded that naive control rats are hyperactive relative to experienced rats in this exploratory situation and that rats with pallidal lesions display changes in their behavior which are characteristic of hyperactive animals even when other tests under similar conditions, such as exploration during the light cycle in a maze, show the pallidal rats as hypoactive relative to control rats.
S Norton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  1     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:    1976 Mar-Apr
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-202     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal / physiology
Circadian Rhythm
Exploratory Behavior
Globus Pallidus / physiopathology*
Hyperkinesis / physiopathology*
Motor Activity / physiology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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