Document Detail

Hyperactivation of parahippocampal region and fusiform gyrus associated with successful encoding in medial temporal lobe epilepsy.
MedLine Citation:
PMID:  21480879     Owner:  NLM     Status:  Publisher    
Purpose:  Performance in recognition memory differs among patients with medial temporal lobe epilepsy (MTLE). We aimed to determine if distinct recognition performances (normal vs. impaired) could be related to distinct patterns of brain activation during encoding. Methods:  Event-related functional magnetic resonance imaging (fMRI) activation profiles were obtained during successful encoding of non-material-specific items, in 14 MTLE patients tested for recognition of stimuli afterward. Findings were compared to those of 25 healthy subjects, and voxel-based correlations were assessed between brain activation and performance. Key Findings:  Patients with left and right MTLE showed similar activations and similar performances. As a whole, the group of patients demonstrated altered recognition scores, but three of the seven patients with left MTLE and three of the seven patients with right MTLE exhibited normal performance relative to controls. In comparison to healthy subjects and patients with impaired recognition, patients with normal recognition showed weaker activations in left opercular cortex, but stronger activations in bilateral parahippocampal region/fusiform gyrus (PH/FG). By contrast, patients with impaired performance showed weaker activations in bilateral PH/FG, but stronger activations in a frontal/cingulate and parietal network. Recognition performance was correlated positively to bilateral PH/FG activations, and negatively correlated to bilateral frontal/cingulate activations, in the whole group of patients, as well as in subgroups of patients with either left or right MTLE. Significance:  These results suggest occurrence of effective functional compensation within bilateral PH/FG in MTLE, allowing patients to maintain recognition capability. In contrast, impairment of this perceptive-memory system may lead to alternative activation of an inefficient nonspecific attentional network in patients with altered performance.
Eric Guedj; Gaelle Bettus; Emmanuel J Barbeau; Catherine Liégeois-Chauvel; Sylviane Confort-Gouny; Fabrice Bartolomei; Patrick Chauvel; Patrick J Cozzone; Jean-Philippe Ranjeva; Maxime Guye
Related Documents :
3808779 - Vascular ring: clinical and physiological assessment of pulmonary function following su...
19787469 - The effects of cachexia and related components on pulmonary functions in patients with ...
9792569 - Inadequate literacy is a barrier to asthma knowledge and self-care.
15104199 - Increased concentrations of glutathione in induced sputum of patients with mild or mode...
18481129 - Cpap compliance in patients with obstructive sleep apnea syndrome.
20830229 - Airway responsiveness to inhaled aspirin is influenced by airway hyperresponsiveness in...
8942739 - Shwachman syndrome: exocrine pancreatic dysfunction and variable phenotypic expression.
1782639 - Selenium therapy in patients with precancerous and malignant oral cavity lesions: preli...
2964449 - Provocation discography as a guide to planning operations on the spine.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-11
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
Center for Magnetic Resonance in Biomedicine (CRMBM), UMR CNRS 6612, Marseille, France Nuclear Medicine Department, Marseille, France Medical Imaging Department (PIM), AP-HM, Marseille, France Medical School, University of the Mediterranean, Marseille, France INSERM U751, Epilepsy and Cognition Unit, Marseille, France Paul Sabatier, University, Brain and Cognition Research Center (CerCo), Toulouse, France CNRS UMR 5549, Toulouse, France Clinical Neurophysiology Department, Marseille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The causes of epilepsy: Changing concepts of etiology of epilepsy over the past 150?years.
Next Document:  Retrospective multiinstitutional study of the prevalence of early death in Dravet syndrome.