Document Detail


Hymecromone in the treatment of motor disorders of the bile ducts: a multicenter, double-blind, placebo-controlled clinical study.
MedLine Citation:
PMID:  11951580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biliary dyskinesia is frequently encountered in clinical practice and is characterized by pain during or after meals. The present study was designed to assess the action of hymecromone in patients with motor disorders of the bile ducts. One hundred twenty-three patients (36 men and 87 women) were enrolled in the multicenter double-blind placebo-controlled study. The mean age was 60.3 years +/- 14.2 SD. Diagnosis was dyspepsia in 58 patients, dyskinesia in 59, cholelithiasis in five and hepatopathy in one. The patients were divided into two groups. One group (61 patients) was treated with hymecromone (300 mg tablets at a dosage of 1,200 mg/day, 2 tablets midday and evening) and another group (62 patients) was treated with placebo. Treatment lasted for 14 days. Control of dyspepsia and pain symptoms of biliary origin was more marked and constant with hymecromone than with placebo. By the end of the treatment, patients in the hymecromone group showed a 70.3% reduction in intensity of spontaneous abdominal pain, while the placebo group showed a 43.8% reduction. Hymecromone was well accepted by the patients and judged to be effective by the investigator in 88.5% of patients treated. The possibility of using hymecromone in 300-mg tablets in the treatment of motor disorders of the bile ducts is thus confirmed.
Authors:
A Abate; V Dimartino; P Spina; P L Costa; C Lombardo; A Santini; M Del Piano; P Alimonti
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  27     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  2001  
Date Detail:
Created Date:  2002-04-15     Completed Date:  2002-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  223-31     Citation Subset:  IM    
Affiliation:
Department of Medicine, Monte lacoviello Hospital, Piazza di Vagno, 4, Santeramo al Colle, 70029 Bari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Bile Duct Diseases / complications,  drug therapy*
Double-Blind Method
Female
Gallbladder / surgery
Gastrointestinal Diseases / chemically induced,  complications
Humans
Hymecromone / adverse effects,  therapeutic use*
Male
Middle Aged
Pain / complications
Parasympatholytics / adverse effects,  therapeutic use*
Prospective Studies
Chemical
Reg. No./Substance:
0/Parasympatholytics; 90-33-5/Hymecromone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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