Document Detail

Hydroxyurea use during pregnancy: a case report in sickle cell disease and review of the literature.
MedLine Citation:
PMID:  9929109     Owner:  NLM     Status:  MEDLINE    
A patient being treated for sickle cell disease with hydroxyurea (1 g/d) conceived, and drug treatment was discontinued at nine weeks gestational age. The pregnancy and delivery were complicated by vaso-occlusive crises. A healthy male infant was born at 39 weeks with no evidence of congenital malformations. A literature review, including this case, suggests that the risk of hydroxyurea exposure during in pregnancy may have been overestimated. Further studies are required to determine its safety in pregnancy.
O Diav-Citrin; L Hunnisett; G D Sher; G Koren
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  60     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  148-50     Citation Subset:  IM    
Department of Pediatrics, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Anemia, Sickle Cell / drug therapy*
Gestational Age
Hydroxyurea / adverse effects*
Infant, Newborn
Pregnancy Complications, Hematologic*
Pregnancy Outcome
Risk Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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