Document Detail


Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?
MedLine Citation:
PMID:  23318979     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hydroxyurea (HU) is a drug that induces fetal hemoglobin production. As a result, HU is widely used to treat β-thalassemia (β-thal) patients. However, the response of these patients to HU varies. Some β-thal patients respond favorably to treatment while others do not respond at all. HU has a number of side-effects and therefore its targeted prescription is beneficial. Hence, identifying the genetic determinants which lead to the differential HU response is important. This review summarizes recent findings which have shed light on this topic. Special emphasis is given to the mechanisms and genetic loci which may govern these differences. These findings have helped identify several single nucleotide polymorphisms which associate with the response to HU in both β-thal and sickle cell disease patients.
Authors:
Mehdi Banan
Related Documents :
17129979 - Analysis of kawasaki disease showing elevated antibody titres of yersinia pseudotubercu...
6363709 - Cold reacting antinuclear antibody in henoch-schönlein purpura.
1054319 - Serial studies of hepatitis-associated antigen and antibody in patients receiving antit...
17076709 - Antihistone antibodies in linear scleroderma variants.
23526369 - Lymphatic malformations of the orbit.
8882419 - Genetic and immunological markers of insulin dependent diabetes in black americans.
17295139 - Epidemiological survey of intraocular inflammation in japan.
6603939 - Circulating immunoglobulin-secreting cells in rheumatoid arthritis.
10112159 - Implementing a clinical information system.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Annals of hematology     Volume:  -     ISSN:  1432-0584     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Evin, Daneshjoo Blvd., Koodakyar St, Tehran, Iran, mbbanan@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chirality transcription and amplification by [2]pseudorotaxanes.
Next Document:  The efficacy of rabbit antithymocyte globulin with cyclosporine in comparison to horse antithymocyte...