Document Detail

Hydroxyurea and lower leg ulcers.
MedLine Citation:
PMID:  8261806     Owner:  NLM     Status:  MEDLINE    
We report four cases of cutaneous lower leg ulcers associated with hydroxyurea treatment for myeloproliferative disorders. This association has been reported in one other series of patients who had chronic myelogenous leukemia and were treated with hydroxyurea. A review of the literature and survey of possible pathogenetic mechanisms is presented.
T V Nguyen; D J Margolis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  52     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-26     Completed Date:  1994-01-26     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-9     Citation Subset:  IM    
Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia 19104-4283.
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MeSH Terms
Hydroxyurea / adverse effects*
Leg Ulcer / chemically induced*,  pathology
Middle Aged
Polycythemia Vera / drug therapy
Primary Myelofibrosis / drug therapy
Skin / pathology
Thrombocytosis / drug therapy
Reg. No./Substance:

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