Document Detail


Hydroxyurea-induced foot ulcer in a case of essential thrombocythaemia.
MedLine Citation:
PMID:  20852510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To illustrate the association between hydroxyurea and the development of ulcers.
METHOD: A case study is presented, in which histological changes, mean corpuscular volume (MCV) and transcutaneous oxygen tension (TcPO2) were all measured and analysed, both during hydroxyurea treatment and following it's discontinuation.
RESULTS: Two months following the cessation of hydroxyurea therapy, the patient's ulcer had healed completely. Biopsy specimens taken before and after its discontinuation showed a considerable improvement in vascularity, with a capillary density 6.28 times higher after discontinuation of the drug. TcPO2 was just 8mmHg at the first measurement, and this increased to 65mmHg at the second.
CONCLUSION: These findings suggest deficient neovascularisation and circulation during hydroxyurea treatment. Changes in MCV also appeared to have an effect on the progress of wound healing, which supports the hypothesis that macroerythrocytosis may be involved in the development of these rare ulcers, via impairment of the microcirculatory rheology.
Authors:
S Tsuchiya; S Ichioka; N Sekiya
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of wound care     Volume:  19     ISSN:  0969-0700     ISO Abbreviation:  J Wound Care     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-11-22     Revised Date:  2011-03-10    
Medline Journal Info:
Nlm Unique ID:  9417080     Medline TA:  J Wound Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  361-4     Citation Subset:  N    
Affiliation:
Department of Plastic and Reconstructive Surgery, Saitama Medical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biopsy
Blood Gas Monitoring, Transcutaneous
Drug Monitoring
Erythrocyte Indices
Female
Foot Ulcer / chemically induced*,  pathology,  therapy
Histological Techniques
Humans
Hydroxyurea / adverse effects*
Neovascularization, Physiologic / drug effects
Nucleic Acid Synthesis Inhibitors / adverse effects*
Skin Care
Surgical Flaps
Thrombocythemia, Essential / blood,  drug therapy*
Wound Healing / drug effects
Chemical
Reg. No./Substance:
0/Nucleic Acid Synthesis Inhibitors; 127-07-1/Hydroxyurea
Comments/Corrections
Erratum In:
J Wound Care. 2011 Feb;20(2):89

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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