Document Detail

Hydroxyurea-induced erythroid differentiation.
MedLine Citation:
PMID:  1166074     Owner:  NLM     Status:  MEDLINE    
Hydroxyurea, a cytotoxic agent which destroys cells in DNA synthesis, has been shown to evoke the differentiation of a small number of hemopoietic precursor cells in the erythroid series of erythropoietically suppressed hypertransfused mice. This effect does not appear to be mediated by erythropoietin (EP) since the simultaneous injection of anti-EP did not alter this response.
N J Rencricca; B S Morse; F C Monette; D Howard; F Stohlman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  149     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-11     Completed Date:  1975-12-11     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1052-4     Citation Subset:  IM    
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MeSH Terms
Antibodies / administration & dosage
Cell Count
Erythropoietin / immunology,  pharmacology
Hematopoietic Stem Cells / drug effects*
Hydroxyurea / pharmacology*
Reg. No./Substance:
0/Antibodies; 11096-26-7/Erythropoietin; 127-07-1/Hydroxyurea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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