Document Detail


Hydroxyurea in two pregnant women with sickle cell anemia.
MedLine Citation:
PMID:  10600098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydroxyurea is classified as an S-phase antineoplastic agent (pregnancy category D). Two women became pregnant while taking hydroxyurea for sickle cell anemia and delivered live infants with no congenital anomalies. Although teratogenic effects of hydroxyurea were reported in animal studies, several case reports suggest the agent may have minimal teratogenic effects on the developing fetus. Fourteen cases of hydroxyurea therapy in pregnant patients with acute or chronic myelogenous leukemia, primary thrombocythemia, or sickle cell disease are reported in the literature. Three pregnancies were terminated by elective abortion; one woman developed eclampsia and delivered a phenotypically normal stillborn infant. All other patients delivered live, healthy infants without congenital anomalies. Further studies with larger numbers of patients receiving hydroxyurea during pregnancy, with longer follow-up of exposed children and more careful assessment of fetotoxic effects, are required before the agent can be promoted as safe in pregnancy.
Authors:
D C Byrd; S R Pitts; C K Alexander
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  19     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-07     Completed Date:  2000-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1459-62     Citation Subset:  IM    
Affiliation:
Department of Pharmacy Practice, Auburn University School of Pharmacy, Alabama, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Sickle Cell / drug therapy*
Antineoplastic Agents / adverse effects,  therapeutic use*
Female
Humans
Hydroxyurea / adverse effects,  therapeutic use*
Pregnancy
Pregnancy Complications / drug therapy*
Teratogens / toxicity
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Teratogens; 127-07-1/Hydroxyurea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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