| Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action. | |
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MedLine Citation:
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PMID: 16002219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was conducted to investigate whether hydroxysafflor yellow A (HSYA) has a protective effect on brain injury after focal cerebral ischemia reperfusion, and to determine the possible mechanism. Behavioral tests were used to evaluate the damage to central nervous system. The infarct volume of brain was assessed in brain slices stained with 2% solution of 2,3,5-triphenyl tetrazolium chloride (TTC). Adult male Wistar rats were subjected to 2h of middle cerebral artery occlusion and 24h of reperfusion. Spectrophotometric assay was used to determine the content of malondialdehyde (MDA), and the activity of total antioxidative capability (T-AOC) and superoxide dismutase (SOD). The results showed that treatment with HSYA (2, 4, 8 mg/kg, i.v.) significantly decreased neurological deficit scores and reduced the percentage of infarction in the ipsilateral hemisphere compared with the model group. At the same time, HSYA treatment significantly attenuated the elevation of MDA content, the decrease in SOD activity, and the T-AOC in the ipsilateral hemisphere and serum. All of these findings suggest that HSYA might provide neuroprotection against cerebral ischemia/reperfusion injury through its antioxidant action. |
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Authors:
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Xinbing Wei; Huiqing Liu; Xia Sun; Fenghua Fu; Xiumei Zhang; Jin Wang; Jie An; Hua Ding |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 386 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-07-25 Completed Date: 2005-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 58-62 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Medicine, Shandong University, Wenhua West Road 44#, Jinan, Shandong 250012, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / chemistry, pharmacology* Brain / drug effects*, metabolism, physiopathology Cerebral Infarction / drug therapy*, physiopathology, prevention & control Chalcone / analogs & derivatives*, chemistry, pharmacology Disease Models, Animal Free Radical Scavengers / metabolism Ischemic Attack, Transient / drug therapy*, metabolism, physiopathology Malondialdehyde / metabolism Molecular Structure Neuroprotective Agents / pharmacology, therapeutic use Oxidative Stress / drug effects, physiology Quinones / chemistry, pharmacology* Rats Reperfusion Injury / drug therapy*, physiopathology, prevention & control Superoxide Dismutase / metabolism Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 0/Neuroprotective Agents; 0/Quinones; 146087-19-6/hydroxysafflor yellow A; 542-78-9/Malondialdehyde; 94-41-7/Chalcone; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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