Document Detail


Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action.
MedLine Citation:
PMID:  16002219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was conducted to investigate whether hydroxysafflor yellow A (HSYA) has a protective effect on brain injury after focal cerebral ischemia reperfusion, and to determine the possible mechanism. Behavioral tests were used to evaluate the damage to central nervous system. The infarct volume of brain was assessed in brain slices stained with 2% solution of 2,3,5-triphenyl tetrazolium chloride (TTC). Adult male Wistar rats were subjected to 2h of middle cerebral artery occlusion and 24h of reperfusion. Spectrophotometric assay was used to determine the content of malondialdehyde (MDA), and the activity of total antioxidative capability (T-AOC) and superoxide dismutase (SOD). The results showed that treatment with HSYA (2, 4, 8 mg/kg, i.v.) significantly decreased neurological deficit scores and reduced the percentage of infarction in the ipsilateral hemisphere compared with the model group. At the same time, HSYA treatment significantly attenuated the elevation of MDA content, the decrease in SOD activity, and the T-AOC in the ipsilateral hemisphere and serum. All of these findings suggest that HSYA might provide neuroprotection against cerebral ischemia/reperfusion injury through its antioxidant action.
Authors:
Xinbing Wei; Huiqing Liu; Xia Sun; Fenghua Fu; Xiumei Zhang; Jin Wang; Jie An; Hua Ding
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  386     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Shandong University, Wenhua West Road 44#, Jinan, Shandong 250012, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / chemistry,  pharmacology*
Brain / drug effects*,  metabolism,  physiopathology
Cerebral Infarction / drug therapy*,  physiopathology,  prevention & control
Chalcone / analogs & derivatives*,  chemistry,  pharmacology
Disease Models, Animal
Free Radical Scavengers / metabolism
Ischemic Attack, Transient / drug therapy*,  metabolism,  physiopathology
Malondialdehyde / metabolism
Molecular Structure
Neuroprotective Agents / pharmacology,  therapeutic use
Oxidative Stress / drug effects,  physiology
Quinones / chemistry,  pharmacology*
Rats
Reperfusion Injury / drug therapy*,  physiopathology,  prevention & control
Superoxide Dismutase / metabolism
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Neuroprotective Agents; 0/Quinones; 146087-19-6/hydroxysafflor yellow A; 542-78-9/Malondialdehyde; 94-41-7/Chalcone; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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