| Hydroxysafflor yellow A protects neuron against hypoxia injury and suppresses inflammatory responses following focal ischemia reperfusion in rats. | |
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MedLine Citation:
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PMID: 18787790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous data demonstrated that hydroxysafflor yellow A (HSYA), a yellow color pigments extracted from the safflower, was an effective agent against focal cerebral ischemia. In the present study we demonstrated that HSYA prevented the injury in cultured cerebral cortical neurons induced by oxygen-glucose deprivation and increased the cell viability, as shown by the inhibition of both LDH and NO efflux. Further, HSYA administered orally 3 d before middle cerebral artery occlusion has the capacity to reduce cerebral infarct size and edema after 2 h cerebral ischemia followed by 24 h reperfusion in rats, and to significantly improve neurological behavior scores. Mean while, treatment with HSYA significantly decreased both mRNA and protein levels of IL-1beta, TNF-alpha in ischemic brain tissue. These results suggested that the protection of HSYA results from, at least in part, suppression of inflammatory responses following focal ischemia reperfusion. |
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Authors:
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Sheng-Ying Ye; Wen-Yuan Gao |
Publication Detail:
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Type: Journal Article Date: 2008-09-12 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 31 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-09-12 Completed Date: 2008-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 1010-5 Citation Subset: IM |
Affiliation:
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School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects, physiology Blotting, Western Brain Edema / pathology, prevention & control Cell Hypoxia / drug effects* Cells, Cultured Chalcone / analogs & derivatives*, pharmacology Female Glucose / deficiency Indicators and Reagents Inflammation / pathology*, prevention & control* Interleukin-1beta / biosynthesis Ischemic Attack, Transient / pathology*, prevention & control*, psychology L-Lactate Dehydrogenase / metabolism Neurons / drug effects* Neuroprotective Agents* Nitric Oxide / metabolism Pregnancy Quinones / pharmacology* Rats Rats, Sprague-Dawley Reperfusion Injury / pathology*, prevention & control* Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Indicators and Reagents; 0/Interleukin-1beta; 0/Neuroprotective Agents; 0/Quinones; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide; 146087-19-6/hydroxysafflor yellow A; 50-99-7/Glucose; 94-41-7/Chalcone; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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