Document Detail

Hydroxyproline to hydroxylysine molar ratio indicates collagen type.
MedLine Citation:
PMID:  76387     Owner:  NLM     Status:  MEDLINE    
By using the molar ratio Hyp to Hyl, types I and II of collagen can be differentiated in 0.5 to 10 mg of dried, defatted tissue. Analyses on human skin, tendon, bone, aorta, cartilage, as well as nucleus pulposus, and annulus fibrosus of intervertebral discs are reported. Analyses of collagen of mesenchymal tissues of other vertebrates are also reported. From amino acid analysis of purified collagen samples published in the literature, the molar ratio Hyp/Hyl was calculated. Type I and type III collagen were differentiated from type II, and the latter was differentiated from type IV collagen. The molar ratios obtained with our analyses followed closely the values from previously reported amino acid analyses on purified collagen.
N Blumenkrantz; G Asboe-Hansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  58     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
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MeSH Terms
Amino Acids / analysis
Collagen / analysis*
Hydroxylysine / analysis*
Hydroxyproline / analysis*
Skin / analysis
Species Specificity
Tissue Distribution
Reg. No./Substance:
0/Amino Acids; 28902-93-4/Hydroxylysine; 51-35-4/Hydroxyproline; 9007-34-5/Collagen

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