| Hydroxyproline in the oesophageal mucosa of patients with progressive systemic sclerosis during omeprazole-induced healing of reflux oesophagitis. | |
| | |
MedLine Citation:
|
PMID: 1793779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hydroxyproline concentration in oesophageal mucosal biopsies was used as an index of collagen in an attempt to evaluate the potential for stricture formation in patients with progressive systemic sclerosis. Eight patients suffering from progressive systemic sclerosis with complicating gastro-oesophageal reflux, 8 patients with idiopathic gastro-oesophageal reflux, and 7 normal controls were compared. Acid gastro-oesophageal reflux was assessed with 24-h pH-metry; degree of oesophagitis was evaluated both endoscopically and histopathologically. The patients with progressive systemic sclerosis were investigated at the start of the study and later when healing of oesophagitis was accomplished with omeprazole therapy. The hydroxyproline concentration was significantly increased (P less than 0.01) in the oesophageal mucosa from patients with progressive systemic sclerosis (median 21.8 nmol/mg) as compared to patients with idiopathic gastro-oesophageal reflux (median 6.4 nmol/mg) and normal controls (median 8.1 nmol/mg). Hydroxyproline concentration in oesophageal mucosa from patients with progressive systemic sclerosis decreased significantly and to a normal level (median 6.5 nmol/pg; P = 0.014) when healing of oesophagitis was achieved. |
| | |
Authors:
|
L Hendel |
Related Documents
:
|
11280529 - Composition of the postprandial refluxate in patients with gastroesophageal reflux dise... 21143009 - Serum hepcidin-25 in comparison to biochemical markers and hematological indices for th... 6345129 - Metoclopramide. an updated review of its pharmacological properties and clinical use. 8586369 - Duodenogastric and non acid gastro-oesophageal reflux in patients with reflux oesophagi... 2920919 - Adenocarcinoma in barrett's oesophagus: an overrated risk. 16698369 - Role of positional instillation of contrast cystography in the algorithm for evaluating... 9507539 - Abnormal vasovagal reaction, autonomic function, and heart rate variability in patients... 468519 - Absence of association between hla antigens and primary open angle glaucoma in israel. 20080069 - Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Alimentary pharmacology & therapeutics Volume: 5 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 1991 Oct |
Date Detail:
|
Created Date: 1992-04-08 Completed Date: 1992-04-08 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 471-80 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, University of Copenhagen, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Biopsy Esophagitis, Peptic / drug therapy*, etiology, pathology Esophagus / drug effects*, metabolism, pathology Female Fibrosis Humans Hydroxyproline / metabolism* Male Middle Aged Mucous Membrane / drug effects, metabolism, pathology Omeprazole / therapeutic use* Scleroderma, Systemic / complications, metabolism* |
| Chemical | |
Reg. No./Substance:
|
51-35-4/Hydroxyproline; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Review article: new developments in the use of 5-aminosalicylic acid in patients with inflammatory b...
Next Document: Tripotassium dicitrato bismuthate: absorption and urinary excretion of bismuth in patients with norm...