| Hydroxylamine dilates resistance blood vessels of the perfused rat kidney and mesentery. | |
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MedLine Citation:
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PMID: 2570844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydroxylamine (ED50 values, 47 +/- 8.9 nmol and 320 +/- 39 nmol) dilates resistance arterioles of the perfused noradrenaline-preconstricted rat kidney and mesentery. In this respect hydroxylamine was approximately 63x and 320x less potent than acetylcholine (ACh) and 15x and 128x less potent than nitroprusside in the two perfused organs studied. The vasodilator effect of hydroxylamine (unlike that of ACh) was unaffected by CHAPS de-endothelialization suggesting that its effect is independent of endothelium-derived relaxing factor (EDRF). |
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Authors:
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P K Moore; L Burrows; R Bhardwaj |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 41 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-10-16 Completed Date: 1989-10-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 426-9 Citation Subset: IM |
Affiliation:
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Biomedical Sciences Division, King's College, University of London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Blood Pressure / drug effects Cholic Acids / pharmacology Hydroxylamines / pharmacology* Male Nitroprusside / pharmacology Rats Rats, Inbred Strains Renal Circulation / drug effects* Splanchnic Circulation / drug effects* Vasodilator Agents* |
| Chemical | |
Reg. No./Substance:
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0/Cholic Acids; 0/Hydroxylamines; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine; 75621-03-3/3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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