| Hydroxyethylstarch 10% is superior to Ringer's solution for preloading before spinal anesthesia for Cesarean section. | |
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MedLine Citation:
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PMID: 10930199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the preloading effect of 500 ml hydroxyethylstarch (HES) 10% with 1 L Lactated Ringer's solution (LR). METHODS: In 40 healthy women undergoing elective Cesarean section HES, 500 ml (n = 20), or LR, IL (n = 20), was administered during 10 min before spinal anesthesia. The incidence of hypotension, (systolic blood pressure < 80% of baseline and < 100 mm Hg), and the amount of ephedrine used to treat it were compared. Also, the incidence of nausea and/or vomiting were recorded. Neonatal outcome was assessed using Apgar scores and umbilical venous and arterial blood gases. RESULTS: The incidence of hypotension was higher in the LR than in HES group (80% vs 40%). Mean minimum systolic blood pressure was lower in the LR than in the HES group (86.1 +/- 12.7 mm Hg vs 99.6 +/- 9.7 mm Hg P < 0.05). Systolic blood pressure < 90 mmHg occurred in two of 20 patients (10%) who received HES vs 11 of 20 patients (55%) who received LR (P < 0.05). More doses of ephedrine were required to treat hypotension in the LRthan in the HES group (35.3 +/- 18.4 mg vs 10.6 +/- 8.6 mg; P < 0.05). The incidence of nausea and/or vomiting was lower in the HES than in the crystalloid group. Neonatal outcome was good and similar in both groups. CONCLUSION: Preloading patients undergoing elective Cesarean section with 500 ml HES 10%, decreases the incidence and severity of spinal-induced hypotension more than preloading with 1 L of LR solution. |
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Authors:
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S M Siddik; M T Aouad; G E Kai; M M Sfeir; A S Baraka |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 47 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-11-08 Completed Date: 2000-11-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: CANADA |
Other Details:
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Languages: eng Pagination: 616-21 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, American University of Beirut, Lebanon. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, Obstetrical / adverse effects, methods* Anesthesia, Spinal / adverse effects, methods* Blood Substitutes / therapeutic use Carbon Dioxide / blood Cesarean Section / adverse effects, methods* Colloids / therapeutic use Ephedrine / therapeutic use Female Fetal Blood / metabolism Hetastarch / therapeutic use* Humans Hypotension / etiology, prevention & control Infant, Newborn Isotonic Solutions / therapeutic use* Oxygen / blood Postoperative Nausea and Vomiting / etiology, prevention & control Preanesthetic Medication / methods Pregnancy Vasoconstrictor Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Colloids; 0/Isotonic Solutions; 0/Vasoconstrictor Agents; 124-38-9/Carbon Dioxide; 299-42-3/Ephedrine; 7782-44-7/Oxygen; 8022-63-7/Ringer's lactate; 9005-27-0/Hetastarch |
| Comments/Corrections | |
Comment In:
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Can J Anaesth. 2000 Jul;47(7):607-10
[PMID:
10930197
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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