Document Detail


Hydroxyethyl starch 130 kd/0.4 and albumin improve CVVH biocompatibility whereas gelatin and hydroxyethyl starch 200 kd/0.5 lead to adverse side effects of CVVH in anesthetized pigs.
MedLine Citation:
PMID:  16680020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both fluid management and renal replacement therapies play a fundamental role in the treatment of critically ill patients. In a recent in vitro study, we have shown specific interactions of different colloids and the hemocompatibility of hemofilters. The present study was performed to compare the five most common fluids for volume resuscitation, i.e., normal saline (SAL), hydroxyethyl starch 130 kd/0.4 (HES130), hydroxyethyl starch 200 kd/0.5 (HES200), albumin (ALB), and gelatin (GEL) with respect to their interaction with continuous venovenous hemofiltration (CVVH) in anesthetized domestic pigs. METHODS: Animals (n = 63) were allocated randomly to the fluid type and the respective subgroups, which were divided into control and CVVH groups (n = 6 ndash; 7 per group). Bolus infusion of group specific fluid was followed by a bolus of heparin and the initiation of hemofiltration in CVVH groups. Thereafter, fluids were infused at constant rates, and heparin application was adjusted to keep the activated clotting time at 200 to 250 s. Hemodynamics, airway pressures, pulmonary gas exchange, diuresis, creatinine clearance, and blood cell counts were investigated during the entire procedure (10 ndash; 12 hours). RESULTS: Basics of in vivo effects of SAL, HES130, and ALB were not altered during CVVH. HES130 and ALB enabled stable hemocompatibility, diuresis, and hemodynamics in the respective groups. In contrast, organ functions were significantly different between control and CVVH groups when animals were treated with GEL or HES200. In particular, during CVVH, HES200 led to reduced platelet counts, deteriorated hemodynamics, and increasing airway pressures during CVVH. GEL led to increasing airway pressures, a decrease in pulmonary gas exchange, deteriorated hemodynamics, altered renal histomorphology, reduced platelet counts, and reduced hemoglobin. CONCLUSIONS: Direct in vivo effects of colloids in anaesthetized and ventilated pigs are not predictable for their effects during CVVH. Interaction between CVVH and every volume substitute occur in a highly specific manner. This observation could be helpful to explain contradictory study results and should be considered for future study designs.
Authors:
Juliane K Unger; Claudia Haltern; Jana-Bara Kobela; Roland Francis; Rolf Rossaint; Christian Grosse-Siestrup
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  25     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-45     Citation Subset:  IM    
Affiliation:
Department of Comparative Medicine and Experimental Animal Sciences, Charité Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany. juliane.unger@charite.de
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MeSH Terms
Descriptor/Qualifier:
Albumins / metabolism
Animals
Biocompatible Materials / chemistry*
Blood Platelets / metabolism
Dose-Response Relationship, Drug
Female
Gelatin / chemistry*
Hemodynamics
Hemofiltration / adverse effects*
Hemoglobins / chemistry
Hetastarch / chemistry*,  pharmacology*
Humans
Lung / pathology
Plasma Substitutes / pharmacology*
Swine
Chemical
Reg. No./Substance:
0/Albumins; 0/Biocompatible Materials; 0/Hemoglobins; 0/Plasma Substitutes; 9000-70-8/Gelatin; 9005-27-0/Hetastarch

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