Document Detail

Hydroxyacyl CoA dehydrogenase, an enzyme important in fat metabolism in different cell types in the islets of Langerhans.
MedLine Citation:
PMID:  334589     Owner:  NLM     Status:  MEDLINE    
The pancreatic islets show a remarkably high activity of L-3-hydroxy-acyl CoA dehydrogenase, an enzyme which operates in the fatty acid cycle by catalyzing the NAD+ oxidation of some of the degradation products. In order to study the distribution pattern of its activity within the islets, samples with different relative contents of A1-, A2- and B-cells were prepared and analyzed. The results show that it is unlikely that either the A1-cells or the enzymatically well equipped A2-cells contribute to the high activity values of the islets. In contrast, the experiments indicated that the high activity was due to the B-cells. After 72 hours starvation, leading to an increase in the serum free fatty acids, there was no change in the activity of the A2-cells, while the B-cells, however, showed a significant but moderate decrease in their activity. It is concluded that the B-cells are enzymatically equipped for the oxidation of fatty acid degradation products even in situations with diminished activity such as occurs during a decrease of the mitochondrial assembly.
A Agren; K Borg; S E Brolin; J Carlman; G Lundqvist
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabète & métabolisme     Volume:  3     ISSN:  0338-1684     ISO Abbreviation:  Diabete Metab     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7604157     Medline TA:  Diabete Metab     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
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MeSH Terms
3-Hydroxyacyl CoA Dehydrogenases / metabolism*
Diabetes Mellitus, Experimental / enzymology
Guinea Pigs
Islets of Langerhans / cytology,  enzymology*
Reg. No./Substance:
EC CoA Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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