Document Detail


Hydroxamic acids: proton donor and acceptor strength for use in drug design.
MedLine Citation:
PMID:  14623605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydroxamic acids, the naturally occurring and synthetic products, generally have low toxicities and are of interest for many therapeutic applications. The present investigation describes the measurement of hydrogen bond donor (HBD) strength of ten hydroxamic acids by measuring their log P(O/W) values. Hydroxamic acid functional group contains two oxygen and one nitrogen atom as the acceptor sites. Thus, HBA strength of these reagents is also computed. A knowledge of these parameters is valuable in the field of toxicology, pharmacology and environmental sciences.
Authors:
Harsha Vanjari; Rama Pande
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  33     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-19     Completed Date:  2004-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  783-8     Citation Subset:  IM    
Affiliation:
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, C.G. 492 010, India.
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MeSH Terms
Descriptor/Qualifier:
Drug Design*
Hydroxamic Acids / chemistry*
Protons*
Chemical
Reg. No./Substance:
0/Hydroxamic Acids; 0/Protons

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