Document Detail

Hydrostatic pressure effects on the lamellar to gyroid cubic phase transition of monolionlein at limited hydration.
MedLine Citation:
PMID:  22894718     Owner:  NLM     Status:  Publisher    
Monoacylglycerol based lipids are highly important model membrane components and attractive candidates for drug encapsulation and as delivery agents. However, optimizing the properties of these lipids for applications requires a detailed understanding of the thermodynamic factors governing the self-assembled structures that they form. Here, we report on the effects of hydrostatic pressure, temperature and water composition on the structural behavior and stability of inverse lyotropic liquid crystalline phases adopted by monolinolein (an unsaturated monoacylglycerol having cis-double bonds at carbon positions 9 and 12) under limited hydration conditions. Six pressure - temperature phase diagrams have been determined using small angle X-ray diffraction at water contents between 15 wt% and 27 wt% water, in the range 10 - 40 (o)C and 1 - 3000 bar. The gyroid bicontinuous cubic (Q(II)(G)) phase is formed at low pressure and high temperatures, transforming to a fluid lamellar (L(α)) phase at high pressures and low temperature via a region of Q(II)(G) / L(α )coexistence. Pressure stabilizes the lamellar phase over the Q(II)(G) phase; at fixed pressure increasing the water content causes the coexistence region to move to lower temperature. These trends are consistent throughout the hydration range studied. Moreover, at fixed temperature, increasing the water composition increases the pressure at which the Q(II)(G) to L(α) transition takes place. We discuss the qualitative effect of pressure, temperature and water content on the stability of the Q(II)(G )phase.
T-Y Dora Tang; Nicholas Brooks; Christoph Jeworrek; Oscar Ces; Nicholas J Terrill; Roland Winter; Richard H Templer; John M Seddon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-15
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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