Document Detail

Hydrops in the cochlea can be induced by sound as well as by static pressure.
MedLine Citation:
PMID:  11077202     Owner:  NLM     Status:  MEDLINE    
The Reissner's membrane (RM) was visualised by confocal microscopy in the isolated temporal bone of the guinea pig. The function of the organ was followed by measuring its physiological response. Static pressure applied in the basal coil caused a distention of the RM in the apical coil into the scala vestibuli. The sensitivity to a test tone was reduced. When the pressure was relieved, the RM returned to its original position and the response recovered. If the increased pressure was maintained, the RM would bulge further. The RM could then be reversibly stretched and return gradually, with a delay, to its original position. Alternatively, it could be over-stretched and return with an over-shoot past its original position toward the organ of Corti. In response to repetitive tone pulses of above 80 dB, hydrops of the RM also developed. This was accompanied by a reduced sensitivity. A slow recovery to the original position, or over-shoot, and return of responsiveness could be seen. Above 106 dB sustained loss was generally seen. It is concluded that the RM can accommodate increased scala media pressure by distention. This will relieve the organ of Corti from part of the pressure and may protect the organ from trauma.
A Flock; B Flock
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  150     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-11     Completed Date:  2000-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  175-88     Citation Subset:  IM    
Department of Physiology and Pharmacology, Division of Physiology II, Karolinska Institutet, S-171 77, Stockholm, Sweden.
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MeSH Terms
Cochlea / physiopathology
Cochlear Diseases / etiology*,  pathology,  physiopathology
Cochlear Microphonic Potentials
Edema / etiology*,  pathology,  physiopathology
Guinea Pigs
Microscopy, Confocal
Sound / adverse effects*

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