| Hydrops fetalis--has there been a change in diagnostic spectrum and mortality? | |
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MedLine Citation:
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PMID: 20446894 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the impact of medical progress on the diagnostic spectrum and outcome of infants with hydrops fetalis (HF). STUDY DESIGN: We reviewed the charts of all live-born HF infants (n = 70) over a 16-year period (1993-2009). Data were compared to two published case series (Wafelman LS, Pollock BH, Kreutzer J, Richards DS, Hutchison AA. Biol Neonate 1999;75:73-81, Gainesville, Florida 1983-1992, n = 62; Simpson JH, McDevitt H, Young D, Cameron AD. Fetal Diagn Ther 2006;21:380-382, Glasgow, UK 1990-2004, n = 30). RESULTS: Only two cases were immune HF. The proportion of infants with unexplained HF (30%), lymphatic (24%), cardiac (17%), hematological (6%) or chromosomal anomalies (6%) did not differ from the published case series. There was also no difference in overall mortality (57% vs. 55% or 67%, respectively). Low gestational age (<34 weeks), low 5-min Apgar scores (<4), and heart failure were independently associated with fatality. CONCLUSION: The diagnostic spectrum and mortality of HF has changed little over the last 25 years. In the future, new techniques in mutational analysis will be needed to reduce the high rate of unexplained cases of HF. |
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Authors:
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Christoph Czernik; Hans Proquitté; Boris Metze; Christoph Bührer |
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Publication Detail:
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Type: Journal Article Date: 2010-05-07 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 24 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 258-63 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Charité University Medical Center, Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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