Document Detail

Hydrops fetalis caused by intrauterine human parvovirus infection.
MedLine Citation:
PMID:  2838664     Owner:  NLM     Status:  MEDLINE    
During a large outbreak of erythema infectiosum in 1987 in Toyama prefecture, Japan, a 32-year-old woman acquired a mild rash on her arms and legs at 18 weeks of gestation. At 26 weeks and 4 days of gestation, the fetus died by hydrops fetalis and pregnancy was terminated. Histological studies of the fetus revealed degeneration of erythroblastic cells in the liver and bone marrow. Extensive extramedullary hematopoiesis and hemosiderin deposits were observed in the liver. Antibody response to human parvovirus B19 virus was demonstrated in maternal sera by ELISA. Furthermore, dot hybridization with the molecularly cloned DNA probe revealed the presence of human parvovirus DNA sequence in the fetal liver, spleen, lung, kidney and placenta. This report describes the first case in Japan of hydrops fetalis caused by human parvovirus B19 infection.
Y Matsunaga; T Matsukura; S Yamazaki; M Sugase; R Izumi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of medical science & biology     Volume:  40     ISSN:  0021-5112     ISO Abbreviation:  Jpn. J. Med. Sci. Biol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1988-08-11     Completed Date:  1988-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0243706     Medline TA:  Jpn J Med Sci Biol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  IM    
Central Virus Diagnostic Laboratory, National Institute of Health, Tokyo.
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MeSH Terms
Edema / etiology*
Fetal Death / etiology*
Parvoviridae Infections / complications*
Pregnancy Complications, Infectious*

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