| Hydrophilic polymer emboli: an under-recognized iatrogenic cause of ischemia and infarct. | |
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MedLine Citation:
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PMID: 20305613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the increased use of percutaneous intravascular diagnostic and therapeutic devices, there is potential for embolization of materials introduced into the vasculature. We report nine cases of foreign body emboli in patients who underwent vascular procedures using hydrophilic-coated medical devices. The procedures performed included cardiac catheterization (four cases), diagnostic cerebral angiography (two cases), therapeutic cerebral angiography with coil embolization of intracerebral aneurysm (one case), lower extremity angiography (one case), and/or orthotopic cadaveric organ transplantation (three cases). Other procedures in these patients included hemodialysis and peripheral arterial or central venous catheterization. Clinical sequelae ranged from undetectable (no symptoms) to pulmonary infarction, stroke, ongoing gangrene, and/or death occurring within days to weeks of suspected embolization of foreign material. Microscopic findings in biopsy or autopsy tissue revealed aggregates of amorphous or lamellated, non-refractile, non-polarizable, predominantly basophilic foreign substances occluding intrapulmonary, intracerebral, or peripheral arteries. This is the largest series documenting embolization of polymer gel materials. Polymer gel is now widely used on several devices for interventional procedures worldwide, and we suspect that complications associated with iatrogenic embolization of this substance are under-recognized. |
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Authors:
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Rupal I Mehta; Rashi I Mehta; Orestes E Solis; Reza Jahan; Noriko Salamon; Jonathan M Tobis; William H Yong; Harry V Vinters; Michael C Fishbein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-19 |
Journal Detail:
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Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Volume: 23 ISSN: 1530-0285 ISO Abbreviation: Mod. Pathol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806605 Medline TA: Mod Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 921-30 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine (Section of Neuropathology), University of California, Los Angeles, CA 90095, USA. RMehta@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Catheterization / adverse effects*, instrumentation Embolism / etiology*, pathology Female Foreign Bodies / complications Gels / adverse effects* Humans Infarction / etiology*, pathology Ischemia / etiology*, pathology Male Middle Aged Polymers / adverse effects* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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NS044378/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gels; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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