Document Detail


Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.
MedLine Citation:
PMID:  19138065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).
Authors:
Semra Colak; Christopher F Nelson; Klaus Nüsslein; Gregory N Tew
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Biomacromolecules     Volume:  10     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-04-13     Revised Date:  2013-07-09    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-9     Citation Subset:  IM    
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts-Amherst, 120 Governors Drive, Amherst, Massachusetts 01003, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemistry*
Bacteria / drug effects
Biocompatible Materials / chemistry
Carbohydrates
Hemolysis / drug effects*
Microbial Sensitivity Tests
Plastics / chemistry,  pharmacology*
Polyethylene
Static Electricity
Grant Support
ID/Acronym/Agency:
U01 AI082192/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Biocompatible Materials; 0/Carbohydrates; 0/Plastics; 0/polynorbornen; 9002-88-4/Polyethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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