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The hydrolysis of striatal adenine- and Guanine-based purines in a 6-hydroxydopamine rat model of Parkinson's disease.
MedLine Citation:
PMID:  21046237     Owner:  NLM     Status:  In-Data-Review    
Parkinson's disease (PD) is characterized by a progressive neurodegeneration in the substantia nigra and a striatal dopamine decrease. Striatal extracellular adenosine and ATP modulate the dopaminergic neurotransmission whereas guanosine has a protective role in the brain. Therefore, the regulation of their levels by enzymatic activity may be relevant to the clinical feature of PD. Here it was evaluated the extracellular nucleotide hydrolysis from striatal slices 4 weeks after a unilateral infusion with 6-OHDA into the medial forebrain bundle. This infusion increased ADP, AMP, and GTP hydrolysis by 15, 25, and 41%, respectively, and decreased GDP hydrolysis by 60%. There was no change in NTPDases1, 2, 3, 5, 6, and 5'-nucleotidase transcription. Dopamine depletion changes nucleotide hydrolysis and, therefore, alters the regulation of striatal nucleotide levels. These changes observed in 6-OHDA-lesioned animals may contribute to the symptoms observed in the model and provide evidence to indicate that extracellular purine hydrolysis is a key factor in understanding PD, giving hints for new therapies.
Jean Pierre Oses; Cristiane Batassini; Daniela Pochmann; Ana Elisa Böhmer; Fernanda Cenci Vuaden; Roberta Bristot Silvestrin; Alcyr Oliveira; Carla Denise Bonan; Maurício Reis Bogo; Diogo Onofre Souza; Luis Valmor Cruz Portela; João José de Freitas Sarkis; Tadeu Mello E Souza
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Publication Detail:
Type:  Journal Article     Date:  2010-11-04
Journal Detail:
Title:  Neurochemical research     Volume:  36     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.
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