| Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet. | |
| | |
MedLine Citation:
|
PMID: 20832797 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The ability of the fatty acid composition of dietary phosphatidylcholine (PC) to affect hepatic lipid levels was investigated in C57BL/6 mice (n=8-10 per group) by feeding: (1) a high-fat semi-purified diet (HF), (2) HF diet supplemented with 1.25 wt% soy PC (SPC), (3) HF with 1.25 wt% hydrogenated soy PC (SPCH), (4) HF with 1.25 wt% egg PC (EPC), and (5) HF with 1.25 wt% hydrogenated egg PC (EPCH). The polyunsaturated fatty acid content (C18:2+C18:3+C20:4) of soy, egg and hydrogenated PC was 70%, 20% and 0%, respectively. Total liver lipid was significantly lower in SPCH and EPCH vs. HF (8.7 ± 0.1 and 8.5 ± 0.5 vs. 11.8 ± 0.6g/100, P<0.05), but not in SPC or EPC. SPCH and EPCH had significantly lower levels of hepatic cholesterol (-52% and -53% vs. HF, respectively). Bioactive lipids (i.e., sphingomyelin and ceramide) were also lower in the liver of SPCH and EPCH rather than in SPC or EPC. Hepatic expression of genes controlling fatty acid synthesis and catabolism were not significantly affected by dietary PC. However, hepatic expression of HMGCR, LDLR and SREBP2 was higher and that of ABCA1, ABCG5 and ABCG8 was reduced in SPCH and EPCH vs. HF. These results demonstrate that hydrogenated PC supplementation reduces hepatic lipid levels in mice fed a high-fat diet supporting the concept that the ability of dietary PC to lower hepatic lipid levels is not due to its content of polyunsaturated fatty acids. |
| | |
Authors:
|
Sally Tandy; Rosanna W S Chung; Alvin Kamili; Elaine Wat; Jacquelyn M Weir; Peter J Meikle; Jeffrey S Cohn |
Related Documents
:
|
16911837 - Impacts of microcystins on the feeding behaviour and energy balance of zebra mussels, d... 2839027 - Peripheral insulin sensitivity as modified by diet and exercise training. 11014217 - Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabe... 12514287 - Detrimental effects of a high fat diet in early renal injury are ameliorated by fish oi... 10521037 - Effects of induced hypothyroidism on ovarian response to superovulation in brahman (bos... 8365077 - Treatment variables and intellectual outcome in children with classic phenylketonuria. ... |
Publication Detail:
|
Type: Journal Article Date: 2010-08-11 |
Journal Detail:
|
Title: Atherosclerosis Volume: 213 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 142-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Nutrition and Metabolism Group, Heart Research Institute, Sydney, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Economic evaluation of nurse staffing and nurse substitution in health care: A scoping review.
Next Document: The evaporation of positive genetic association findings. When time has come to go.