Document Detail

Hydrogenated fat intake during pregnancy and lactation modifies serum lipid profile and adipokine mRNA in 21-day-old rats.
MedLine Citation:
PMID:  18178060     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined whether feeding pregnant and lactating rats hydrogenated fats rich in trans-fatty acids modifies the plasma lipid profiles and the expression of adipokines involved with insulin resistance and cardiovascular disease in their 21-d-old offspring. METHODS: Pregnant and lactating Wistar rats were fed with a control diet (C group) or one enriched with hydrogenated vegetable fat (T group). After delivery, male offspring were weighed weekly and killed at day 21 of life by decapitation. Blood and retroperitoneal, epididymal, and subcutaneous white adipose tissues were collected. RESULTS: Offspring of T-group rats had increased serum triacylglycerols and cholesterol, white adipose tissue plasminogen activator inhibitor-1, and tumor necrosis factor-alpha gene expression, and carcass lipid content and decreased blood leptin and adiponectin and adiponectin gene expression. CONCLUSION: Ingestion of hydrogenated vegetable fat by the mother during gestation and lactation alters the blood lipid profiles and the expression of proinflammatory adipokynes by the adipose tissue of offspring aged 21 d.
Luciana P Pisani; Lila M Oyama; Allain A Bueno; Carolina Biz; Kelse T Albuquerque; Eliane B Ribeiro; Claudia M Oller do Nascimento
Publication Detail:
Type:  Journal Article     Date:  2008-01-04
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  24     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
Department of Physiology, Division of Nutrition Physiology, São Paulo Federal University-UNIFESP, São Paulo, Brazil.
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MeSH Terms
Adipokines / metabolism*
Adipose Tissue / metabolism*
Cholesterol / blood
Dietary Fats / administration & dosage*
Insulin Resistance*
Lipids / blood*
Plasminogen Activator Inhibitor 1 / metabolism
Prenatal Exposure Delayed Effects
RNA, Messenger / analysis,  metabolism
Rats, Wistar
Trans Fatty Acids / administration & dosage,  metabolism
Triglycerides / blood
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Adipokines; 0/Dietary Fats; 0/Lipids; 0/Plasminogen Activator Inhibitor 1; 0/RNA, Messenger; 0/Trans Fatty Acids; 0/Triglycerides; 0/Tumor Necrosis Factor-alpha; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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